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Apart from extra effort involved in soldering up two boards, and fitting two boards into a single enclosure, there shouldn't be any major issues to consider. If you are hardwiring it so both effects are engaged at the same time, I assume it will go overdrive->reverb. It this case, you might want to consider how you will implement the volume control (I.e. volume control on output of overdrive before reverb input so you can avoid overdriven the input of the reverb, but do you then need a second master output control after the reverb?).
As more general advice, I would urge you to wire up the boards to try them out together first before you put a drill anywhere near an enclosure.
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