I imagine it will depend on your level of electronics knowledge.
If you know your way way around it a bit but are not an expert/engineer I'd say the best circuits for tweaks/mods are the most common for the simple reason that you can find very good circuit analysis and explanations online.
One you have the circuits dissected and explained it is a lot easier to get modifying as you know where to put your hands according to what you want to change.
Alternatively, you can take a simple circuit (ie Fuzz Face and variants, Bazz Fuss etc) and "pimp it by seeing how a buffer stage can change its tone/responsiveness, adding a tone control, additional clipping etc...